Arterial load and right ventricular-vascular coupling in pulmonary hypertension
Hannah T. Oakland, Phillip Joseph, Robert Naeije, Ahmed Elassal, Marjorie Cullinan, Paul M. Heerdt, Inderjit Singh
Abstract
Pulmonary vascular impedance (PVZ) represents the most comprehensive measure of right ventricle (RV) afterload; however, measurement of this variable is complex. We demonstrate that characteristic impedance ( Z c ) and a wave reflection coefficient, λ, can be derived from RV pressure waveform analysis. In addition, RV dysfunction in left heart disease is independent of its afterload. The current study provides a platform for future studies to examine the pharmacotherapeutic effects and prognosis of different measures of RV afterload.
Topics & Concepts
AfterloadCardiologyVentricleInternal medicineMedicinePulmonary hypertensionWaveformBlood pressurePhysicsVoltageQuantum mechanicsPulmonary Hypertension Research and TreatmentsCardiovascular Function and Risk FactorsHemodynamic Monitoring and Therapy