Deficiency of BCAT2-mediated branched-chain amino acid catabolism promotes colorectal cancer development

Zi‐Ran Kang, Shanshan Jiang, Ji‐Xuan Han, Yaqi Gao, Yile Xie, Jinxian Chen, Qiang Liu, Jun Yu, Xin Zhao, Jie Hong, Haoyan Chen, Haoyan Chen, Yingxuan Chen, Huimin Chen, Huimin Chen, Jing‐Yuan Fang

2023Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease48 citationsDOI

Topics & Concepts

AzoxymethanemTORC1Colorectal cancerCatabolismCarcinogenesisCancer researchCancerCell growthBiologyMetabolismEndocrinologyBranched-chain amino acidInternal medicineChemistryApoptosisAmino acidBiochemistryMedicinePI3K/AKT/mTOR pathwayLeucineAmino Acid Enzymes and MetabolismMetabolomics and Mass Spectrometry StudiesFerroptosis and cancer prognosis