Engineered mesoporous silica-based nanoparticles as smart chemotherapy nanodevice for bortezomib administration
Marzia De Santo, A. Giovinazzo, Mariarosa Fava, Elisabetta Mazzotta, Ilaria Napoli, Marianna Greco, Alessandra Comandé, Alessandra Nigro, Pietro Argurio, Ida Perrotta, Mariano Davoli, A. Tagarelli, R. Elliani, T. Granato, G. Nicolini, A. Chiorazzi, S. Semperboni, E. Ballarini, C. Crocamo, G. Cavaletti, Domenico Lombardo, Diego Sisci, Catia Morelli, Antonella Leggio, Luigi Pasqua
Abstract
Engineered mesoporous silica-based nanostructures for selective and pH-sensitive release of the anticancer drug bortezomib. The developed “smart chemotherapy” showed higher efficacy in vivo compared to traditional free bortezomib administration.
Topics & Concepts
NanodeviceBortezomibMesoporous silicaIn vivoNanomedicineMaterials scienceNanotechnologyNanoparticlePharmacologyMesoporous materialChemistryMedicineMultiple myelomaOrganic chemistryInternal medicineBiologyCatalysisBiotechnologyNanoparticle-Based Drug DeliveryGraphene and Nanomaterials ApplicationsNanomaterials for catalytic reactions