Photoredox radical/polar crossover enables C–H <i>gem</i>-difunctionalization of 1,3-benzodioxoles for the synthesis of monofluorocyclohexenes
Jiabao Tian, Lei Zhou
Abstract
A sequential C–H gem -difunctionalization of 1,3-benzodioxoles with α-trifluoromethyl alkenes and electron-deficient alkenes in a redox-neutral radical polar crossover manifold have been developed for the synthesis of monofluorocyclohexenes.
Topics & Concepts
PolarChemistryCrossoverRadicalCombinatorial chemistryStereochemistryMedicinal chemistryOrganic chemistryComputer sciencePhysicsAstronomyArtificial intelligenceFluorine in Organic ChemistryRadical Photochemical ReactionsSulfur-Based Synthesis Techniques