Glycerol-3-phosphate contributes to the increase in FGF23 production in chronic kidney disease
Petra Šimić, Xie Han, Qian Zhang, Wen Zhou, Rohan Cherukuru, Michael A. Adams, Mandy E. Turner, Eugene P. Rhee
Abstract
This study shows that glycerol-3-phosphate, a glycolytic by-product recently implicated in a kidney-to-bone signaling axis that regulates FGF23 production, increases in mice and rats with CKD. Furthermore, mice deficient in a key enzyme that synthesizes glycerol-3-phosphate have attenuated increases in both glycerol-3-phosphate and FGF23 in CKD, along with enhanced cortical bone loss. These studies identify glycerol-3-phosphate as a novel regulator of FGF23 and mineral metabolism in CKD.
Topics & Concepts
Fibroblast growth factor 23Kidney diseaseInternal medicinePhosphateEndocrinologyGlycerolKidneyDehydrogenaseChemistryMedicineBiologyEnzymeBiochemistryCalciumParathyroid hormoneParathyroid Disorders and TreatmentsFibroblast Growth Factor ResearchBiomedical Research and Pathophysiology