Remote arylalkylation of unactivated alkenes<i>via</i>6- or 7-membered nickelacycles with excellent diastereofidelity
Junsong Zhao, Lin‐Yan Bao, Lin Zhu, Lei Zhao, Luyao Ding, Wei Guan, Chao Wang
Abstract
We developed a nickel-catalyzed remote arylalkylation of unactivated alkenes via kinetically and thermodynamically disfavored 6- and 7-membered nickelacycles.
Topics & Concepts
ChemistryNickelCatalysisCombinatorial chemistryMedicinal chemistryOrganic chemistryCatalytic C–H Functionalization MethodsCatalytic Alkyne ReactionsAsymmetric Hydrogenation and Catalysis