NIR-II imaging of hepatocellular carcinoma based on a humanized anti-GPC3 antibody
Hui Shi, Lakshmi Huttad, Mingdian Tan, Hongguang Liu, Mei‐Sze Chua, Zhen Cheng, Samuel So
Abstract
A NIR-II fluorescence probe was synthesized based on a humanized anti-GPC3 antibody and ICG for HCC targeted NIR-II imaging. GPC3-ICG showed specific HCC cell line and Huh-7 tumor targeting imaging capability.
Topics & Concepts
Indocyanine greenHepatocellular carcinomaFluorescence-lifetime imaging microscopyIn vivoEx vivoMedicineCancer researchPreclinical imagingGlypican 3AutofluorescencePathologyFluorescenceBiologyQuantum mechanicsBiotechnologyPhysicsNanoplatforms for cancer theranosticsCancer, Stress, Anesthesia, and Immune ResponseHepatocellular Carcinoma Treatment and Prognosis