TBAI/K<sub>2</sub>S<sub>2</sub>O<sub>8</sub>-Promoted [4 + 2] Annulation of Ketene <i>N</i>,<i>S</i>-Acetals and <i>N</i>-Tosylhydrazones toward Pyridazines
Zhuqing Liu, Jiang Lou, Jiaqi Xiao
Abstract
-tosylhydrazones was efficiently developed, enabling straightforward access to a variety of trisubstituted pyridazines in reasonable to good yields. The synthetic methodology features a broad substrate scope and a good functional group tolerance. Control experiments demonstrated the indispensability of the alkylthio functionality in the enaminone substrates.
Topics & Concepts
KeteneAnnulationChemistryScope (computer science)Functional groupSubstrate (aquarium)Combinatorial chemistryMedicinal chemistryOrganic chemistryCatalysisComputer scienceEcologyProgramming languagePolymerBiologySynthesis of heterocyclic compoundsSynthesis and Catalytic ReactionsSulfur-Based Synthesis Techniques