A pH-responsive hyaluronic acid hydrogel for regulating the inflammation and remodeling of the ECM in diabetic wounds
Yile Jia, Xianhui Zhang, Weihu Yang, Chuanchuan Lin, Bailong Tao, Zhiwen Deng, Pengfei Gao, Yulu Yang, Kaiyong Cai
Abstract
A “Double H-bonds” crosslinked hyaluronic acid–collagen hydrogel can effectively reduce inflammation and promote collagen deposition at wound sites, thus promoting wound closure in diabetic mice.
Topics & Concepts
Hyaluronic acidInflammationWound healingSelf-healing hydrogelsWound closureTissue remodelingChemistryMaterials scienceMedicinePolymer chemistryInternal medicineSurgeryAnatomyWound Healing and TreatmentsElectrospun Nanofibers in Biomedical ApplicationsPeriodontal Regeneration and Treatments