N-Heterocyclic carbene (NHC)-catalyzed intramolecular benzoin condensation–oxidation
Killari Satyam, Jakkula Ramarao, Surisetti Suresh
Abstract
NHC-Catalyzed intramolecular benzoin condensation-oxidation is developed for the expedient synthesis of diverse cyclic 1,2-diketones incorporated in dibenzo-fused seven-membered heterocycles in good to excellent yields, under ambient conditions. The presented carbene-catalyzed transformation appears to proceed through the benzoin intermediate followed by aerobic oxidation.
Topics & Concepts
BenzoinIntramolecular forceCarbeneCatalysisCondensationChemistryUmpolungOrganic chemistryPolymer chemistryMedicinal chemistryCombinatorial chemistryPhotochemistryThermodynamicsPhysicsNucleophileN-Heterocyclic Carbenes in Organic and Inorganic ChemistryCatalytic Cross-Coupling ReactionsSynthetic Organic Chemistry Methods