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Manganese disrupts the maturation and degradation of axonal autophagosome leading to hippocampal synaptic toxicity in mice via the activation of LRRK2 on phosphorylation of Rab10

Zhuo Ma, Kuan Liu, Ruifeng Zhang, Zixin Xie, Wei Liu, Bin Xu

2024The Science of The Total Environment7 citationsDOI

Topics & Concepts

Cell biologyHippocampal formationAutophagyKinasePhosphorylationAxoplasmic transportBiologyLRRK2Synaptic vesicleAxonChemistryNeuroscienceBiochemistryVesicleApoptosisMutationMembraneGeneAlzheimer's disease research and treatmentsNeuroscience and Neuropharmacology ResearchAutophagy in Disease and Therapy
Manganese disrupts the maturation and degradation of axonal autophagosome leading to hippocampal synaptic toxicity in mice via the activation of LRRK2 on phosphorylation of Rab10 | Litcius