The impact of radiation on lymphedema: a review of the literature
Omar Allam, Kitae E. Park, Ludmila Chandler, Mohammad Ali Mozaffari, Maham Ahmad, Xiaona Lu, Michael Alperovich
Abstract
Radiation therapy (RT) is a common adjunct therapy in oncology. However, it carries a significant risk of lymphedema when utilized in some anatomic locations. Recent studies have provided insight into lymphedema pathophysiology, diagnostic techniques, and RT. This review will examine the role of RT in upper and lower extremity lymphedema. Radiation's role in increasing the risk of lymphedema through decreased lymphatic proliferation potential, interstitial fibrosis compressing lymphatic vessels, and mechanical insufficiency of the lymphatic system will be reviewed.
Topics & Concepts
LymphedemaMedicineLymphatic systemRadiation therapySecondary lymphedemaFibrosisPathophysiologyRadiologyPathologyCancerInternal medicineBreast cancerLymphatic System and DiseasesSystemic Sclerosis and Related DiseasesBody Contouring and Surgery