Dynamical systems theory of cellular reprogramming
Yuuki Matsushita, Tetsuhiro Hatakeyama, Kunihiko Kaneko
Abstract
The authors present a theoretical mechanism for cellular reprogramming and show that global attraction to the initial unstable pluripotent-state is achieved only by manipulating the expression of few genes.
Topics & Concepts
ReprogrammingComputer scienceBiologyGeneticsCellPluripotent Stem Cells ResearchGene Regulatory Network AnalysisCRISPR and Genetic Engineering