Synthesis, biological evaluation and model membrane studies on metal complexes containing aromatic N,O-chelate ligands
Alberto Aragón-Muriel, Yamil Liscano, Ernesto Rufino‐Felipe, David Morales‐Morales, José Oñate-Garzón, Dorian Polo‐Cerón
Abstract
ATCC 27583) using the microdilution method. The results obtained show that the metal complexes exhibit higher biological activity than the free ligands, confirming a synergistic effect. Further benzimidazolyl-phenol derivatives were explored for the detection of bacteria using fluorescence imaging studies. Interestingly, the fluorescent properties of these compounds make them potential candidates to monitor the morphology of bacteria at different compound concentrations. Hence, the interaction of the ligand and complexes with model membranes mimicking those of bacteria was studied by using differential scanning calorimetry (DSC) and molecular dynamics (MD), showing that both compounds decreased the enthalpy of transition in two model membranes as the concentration of the compounds increased. In addition, the main transition temperature was slightly reduced as a result of these interactions.