Aptamer-aided plasmonic nano-urchins for reporter-free surface-enhanced Raman spectroscopy analysis of cortisol
Chengyu Li, Jing Hu, Nan Hu, Jianjun Zhao, Qianwen Li, Yanhui Han, Yanxiong Liu, Xufang Hu, Liyan Zheng, Qiue Cao
Abstract
), robust salt (1.0 mol per L NaCl) and protein (5.0 mg per mL bovine serum protein) tolerance, favorable reproducibility, as well as good reusability. We further demonstrated the good cortisol-capturing ability and SERS efficacy of the α-FeOOH@Au-aptamer profiling in the serum and urine samples. Our approach provides an alternative tool for cortisol analysis and a reference strategy for report-free SERS detection of small molecules.
Topics & Concepts
Surface-enhanced Raman spectroscopyAptamerRaman spectroscopyPlasmonChemistrySurface plasmonNano-NanotechnologyBiophysicsMaterials scienceBiologyMolecular biologyOptoelectronicsPhysicsRaman scatteringOpticsComposite materialStress Responses and CortisolGold and Silver Nanoparticles Synthesis and ApplicationsSpectroscopy Techniques in Biomedical and Chemical Research