Striatal μ-opioid receptor activation triggers direct-pathway GABAergic plasticity and induces negative affect
Wei Wang, Xueyi Xie, Xiaowen Zhuang, Yufei Huang, Tao Tan, Himanshu Gangal, Zhenbo Huang, William Purvines, Xuehua Wang, Alexander Stefanov, Ruifeng Chen, Lucas Rodriggs, Anita Chaiprasert, Emily Yu, Valerie Vierkant, Michelle A. Hook, Yun Huang, Emmanuel Darcq, Jun Wang
Abstract
neurons rescued fentanyl withdrawal-induced physical symptoms and anxiety-like behaviors. These data suggest that chronic opioid use triggers GABAergic striatopallidal and striatonigral plasticity to induce a hypodopaminergic state, which may promote negative emotions and relapse.
Topics & Concepts
GABAergicNeuroscienceDopaminergicMedium spiny neuronOpioidConditioned place preferenceVentral tegmental areaDirect pathway of movementStriatumPsychologyMedicineDopamineReceptorInternal medicineInhibitory postsynaptic potentialNeurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchPain Mechanisms and Treatments