Base catalyzed one-pot thia-Michael addition-oxidation reaction of hetero-aromatic thiols to 2-aryl-3-nitro-2<i>H</i>-chromenes and their antibacterial evaluation
Barsha Samanta, Bhabani Shankar Panda, Seetaram Mohapatra, Sabita Nayak, Debdutta Bhattacharya, Chita Ranjan Sahoo
Abstract
A thia-Michael addition reaction was developed for the synthesis of heteroaromatic thiol-based 2 H -chromenes and the antibacterial activity was studied against two pathogenic bacterial strains, E. coli , and S. aureus .
Topics & Concepts
ChemistryNitroArylCatalysisBase (topology)Michael reactionCombinatorial chemistryMedicinal chemistryOrganic chemistryMathematical analysisMathematicsAlkylSynthesis and biological activitySynthesis of heterocyclic compoundsMulticomponent Synthesis of Heterocycles