Distributed 2D temperature sensing during nanoparticles assisted laser ablation by means of high-scattering fiber sensors
Zhannat Ashikbayeva, Arman Aitkulov, Madina Jelbuldina, Aizhan Issatayeva, Aidana Beisenova, Carlo Molardi, Paola Saccomandi, Wilfried Blanc, Vassilis J. Inglezakis, Daniele Tosi
Abstract
The high demand in effective and minimally invasive cancer treatments, namely thermal ablation, leads to the demand for real-time multi-dimensional thermometry to evaluate the treatment effectiveness, which can be also assisted by the use of nanoparticles. We report the results of 20-nm gold and magnetic iron oxide nanoparticles-assisted laser ablation on a porcine liver phantom. The experimental set-up consisting of high-scattering nanoparticle-doped fibers was operated by means of a scattering-level multiplexing arrangement and interrogated via optical backscattered reflectometry, together with a solid-state laser diode operating at 980 nm. The multiplexed 2-dimensional fiber arrangement based on nanoparticle-doped fibers allowed an accurate superficial thermal map detected in real-time.