Manganese(I)-Catalyzed Asymmetric Hydrophosphination of α,β-Unsaturated Carbonyl Derivatives
Roxana Postolache, Juana M. Pérez, Marta Castiñeira Reis, Luo Ge, Esther G. Sinnema, Syuzanna R. Harutyunyan
Abstract
Here we report catalytic asymmetric hydrophosphination of α,β-unsaturated carbonyl derivatives using a chiral Mn(I) complex as a catalyst. Through H-P bond activation, various phosphine-containing chiral products can be accessed via hydrophosphination of various ketone-, ester-, and carboxamide-based Michael acceptors.
Topics & Concepts
ChemistryCatalysisPhosphineKetoneManganeseOrganic chemistryCombinatorial chemistryMedicinal chemistryAsymmetric Hydrogenation and CatalysisChemical Synthesis and AnalysisOrganophosphorus compounds synthesis