Design, synthesis ADMET and molecular docking of new imidazo[4,5-b]pyridine-5-thione derivatives as potential tyrosyl-tRNA synthetase inhibitors
Ismail M. M. Othman, Mohamed A. M. Gad‐Elkareem, El Hassane Anouar, Kaïss Aouadi, Adel Kadri, Mejdi Snoussi
Topics & Concepts
ChemistryDocking (animal)AntimicrobialActive siteEnzymeStereochemistryPyridineIn vitroChloramphenicolCombinatorial chemistryStructure–activity relationshipBiochemistryAntibioticsOrganic chemistryMedicineNursingRNA and protein synthesis mechanismsSynthesis and biological activityCancer therapeutics and mechanisms