Intermolecular CDC amination of remote and proximal unactivated C<sub>sp<sup>3</sup></sub>–H bonds through intrinsic substrate reactivity – expanding towards a traceless directing group
Suresh Rajamanickam, Mayank Saraswat, Sugumar Venkataramani, Bhisma K. Patel
Abstract
). Computations predicted the radical stability (thermodynamic factors) and the kinetic barriers as the factors responsible for such trends. Remarkably, this strategy eludes any designer catalysts, and the selectivity is due to the intrinsic substrate reactivity.
Topics & Concepts
Intermolecular forceReactivity (psychology)Substrate (aquarium)ChemistryAminationGroup (periodic table)PhotochemistryCrystallographyStereochemistryMoleculeCatalysisOrganic chemistryBiologyMedicineAlternative medicineEcologyPathologySynthesis and Catalytic ReactionsCatalytic C–H Functionalization MethodsFluorine in Organic Chemistry