Manganese(<scp>ii</scp>) complexes stimulate antitumor immunity <i>via</i> aggravating DNA damage and activating the cGAS-STING pathway
Linxiang Cai, Ying Wang, Yayu Chen, Hanhua Chen, Tao Yang, Shuren Zhang, Zijian Guo, Xiaoyong Wang
Abstract
Mn complexes act as breakers of DNA to induce DSB, as inhibitors of HDAC and PARP to impede DNA repair, and as activators of the cGAS-STING pathway to trigger immune responses, thereby stimulating T cells to suppress tumor growth in a synergic mechanism.
Topics & Concepts
ManganeseImmunityInnate immune systemChemistryDNAStingAggravating FactorCell biologyMicrobiologyBiologyBiochemistryImmune systemImmunologyReceptorMedicineEngineeringOrganic chemistryAerospace engineeringDermatologyinterferon and immune responsesCytokine Signaling Pathways and InteractionsInflammasome and immune disorders