Antibiotic Production and Antibiotic Resistance: The Two Sides of AbrB1/B2, a Two-Component System of Streptomyces coelicolor
Ricardo Sánchez de la Nieta, Sergio Antoraz, Juan F. Álzate, Ramón I. Santamaría, Margarita Díaz
Abstract
spp. makes it a valuable tool for improving antibiotic production and the discovery of cryptic metabolites with antibiotic action. On the other hand, AbrB1/B2 contributes to vancomycin resistance and is a homolog of VraR/S and LiaR/S, important regulators in clinically relevant antibiotic-resistant bacteria. Therefore, the study of AbrB1/B2 could provide new insight into the mechanism of this type of resistance.
Topics & Concepts
Streptomyces coelicolorActinorhodinAntibiotic resistanceBiologyVancomycinAntibioticsStreptomycesMicrobiologyGene clusterEnterococcus faecalisStaphylococcus aureusGeneticsGeneBacteriaMicrobial Natural Products and BiosynthesisMicrobial Metabolism and ApplicationsGenomics and Phylogenetic Studies