IL-33/ST2 induces neutrophil-dependent reactive oxygen species production and mediates gout pain
Chengyu Yin, Boyu Liu, Yuanyuan Li, Xiaojie Li, Jie Wang, Ruixiang Chen, Yan Tai, Qiyang Shou, Ping Wang, Xiaomei Shao, Yi Liang, Hong Zhou, Wen‐Li Mi, Jianqiao Fang, Boyi Liu
Abstract
We demonstrated a previous unidentified role of IL-33/ST2 in mediating pain hypersensitivity and inflammation in a mouse gout model through promoting neutrophil-dependent ROS production and TRPA1 channel activation. Targeting IL-33/ST2 may represent a novel therapeutic approach to ameliorate gout pain and inflammation.
Topics & Concepts
Reactive oxygen speciesGoutChemistryInflammationOxygenMedicinePharmacologyImmunologyBiochemistryOrganic chemistryIL-33, ST2, and ILC PathwaysEosinophilic EsophagitisGout, Hyperuricemia, Uric Acid