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A new framework for novel analogues of pazopanib as potent and selective human carbonic anhydrase inhibitors: Design, repurposing rational, synthesis, crystallographic, in vivo and in vitro biological assessments

Salma M. Hefny, Tarek F. El‐Moselhy, Nabaweya Sharaf El-Din, Andrea Ammara, Andrea Angeli, Marta Ferraroni, Ahmed M. El‐Dessouki, Moataz A. Shaldam, Galal Yahya, Ahmed A. Al‐Karmalawy, Claudiu T. Supuran, Haytham O. Tawfik

2024European Journal of Medicinal Chemistry43 citationsDOIOpen Access PDF

Topics & Concepts

ChemistryRepurposingCarbonic anhydrase IIIn vivoIn vitroCarbonic anhydraseRational designStereochemistryPharmacologyPazopanibStructure–activity relationshipCombinatorial chemistryBiochemistryComputational biologyEnzymeNanotechnologyBiologyRenal cell carcinomaOncologyMaterials scienceBiotechnologyMedicineSunitinibEcologyEnzyme function and inhibitionSynthesis and Catalytic ReactionsCoagulation, Bradykinin, Polyphosphates, and Angioedema
A new framework for novel analogues of pazopanib as potent and selective human carbonic anhydrase inhibitors: Design, repurposing rational, synthesis, crystallographic, in vivo and in vitro biological assessments | Litcius