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Vanadium-Catalyzed Dinitrogen Reduction to Ammonia via a [V]═NNH<sub>2</sub> Intermediate

Wenshuang Huang, Ling‐Ya Peng, Jiayu Zhang, Chenrui Liu, Guoyong Song, Ji‐Hu Su, Wei‐Hai Fang, Ganglong Cui, Shaowei Hu

2023Journal of the American Chemical Society41 citationsDOI

Abstract

The catalytic transformation of N 2 to NH 3 by transition metal complexes is of great interest and importance but has remained a challenge to date. Despite the essential role of vanadium in biological N 2 fixation, well-defined vanadium complexes that can catalyze the conversion of N 2 to NH 3 are scarce. In particular, a V(N x H y ) intermediate derived from proton/electron transfer reactions of coordinated N 2 remains unknown. Here, we report a dinitrogen-bridged divanadium complex bearing POCOP (2,6-( t Bu 2 PO) 2 -C 6 H 3 ) pincer and aryloxy ligands, which can serve as a catalyst for the reduction of N 2 to NH 3 and N 2 H 4 . Low-temperature protonation and reduction of the dinitrogen complex afforded the first structurally characterized neutral metal hydrazido(2−) species ([V]═NNH 2 ), which mediated 15 N 2 conversion to 15 NH 3, indicating that it is a plausible intermediate of the catalysis. DFT calculations showed that the vanadium hydrazido complex [V]═NNH 2 possessed a N–H bond dissociation free energy (BDFE N–H ) of as high as 59.1 kcal/mol. The protonation of a vanadium amide complex ([V]–NH 2 ) with [Ph 2 NH 2 ][OTf] resulted in the release of NH 3 and the formation of a vanadium triflate complex, which upon reduction under N 2 afforded the vanadium dinitrogen complex. These transformations model the final steps of a vanadium-catalyzed N 2 reduction cycle. Both experimental and theoretical studies suggest that the catalytic reaction may proceed via a distal pathway to liberate NH 3 . These findings provide unprecedented insights into the mechanism of N 2 reduction related to FeV nitrogenase.

Topics & Concepts

ChemistryVanadiumCatalysisProtonationPincer movementCatalytic cycleTransition metalDissociation (chemistry)AmmoniaTrifluoromethanesulfonateMedicinal chemistryPhotochemistryTransition stateSelective catalytic reductionInorganic chemistryReactive intermediateOrganic chemistryIonAmmonia Synthesis and Nitrogen ReductionMetalloenzymes and iron-sulfur proteinsHydrogen Storage and Materials
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