Role of miRNA in Melanoma Development and Progression
Agata Poniewierska-Baran, Sylwia Słuczanowska-Głąbowska, Paulina Małkowska, Olga Sierawska, Łukasz Zadroga, Andrzej Pawlik, Paulina Niedźwiedzka‐Rystwej
Abstract
Melanoma is one of the most aggressive and progressive skin cancers. It develops from normal pigment-producing cells known as melanocytes, so it is important to know the mechanism behind such transformations. The study of metastasis mechanisms is crucial for a better understanding the biology of neoplastic cells. Metastasis of melanoma, or any type of cancer, is a multi-stage process in which the neoplastic cells leave the primary tumour, travel through the blood and/or lymphatic vessels, settle in distant organs and create secondary tumours. MicroRNA (miRNA) can participate in several steps of the metastatic process. This review presents the role of miRNA molecules in the development and progression as well as the immune response to melanoma.