Discovery of tetrahydroquinolines and benzomorpholines as novel potent RORγt agonists
Yuehan Xia, Mingcheng Yu, Yunpeng Zhao, Li Xia, Yafei Huang, Nannan Sun, Meiqi Song, Huimin Guo, Yunyi Zhang, Di Zhu, Qiong Xie, Yonghui Wang
Topics & Concepts
RAR-related orphan receptor gammaChemistryNuclear receptorAgonistOrphan receptorInverse agonistLinkerReporter geneStereochemistryPartial agonistReceptorCoactivatorPharmacologyBiochemistryGene expressionTranscription factorGeneMedicineOperating systemComputer sciencePsoriasis: Treatment and PathogenesisIL-33, ST2, and ILC PathwaysAutoimmune Bullous Skin Diseases