The endoplasmic reticulum membrane complex promotes proteostasis of GABAA receptors
Angela L. Whittsette, Yajuan Wang, Ting‐Wei Mu
Abstract
receptor variants. In addition, EMC3 and EMC6 demonstrate endogenous interactions with major neuroreceptors, which depends on their transmembrane domains, suggesting a general role of the EMC in the biogenesis of neuroreceptors.
Topics & Concepts
Endoplasmic reticulumGABAA receptorCell biologyBiogenesisProteostasisChemistryReceptorBiologyBiochemistryGeneNeuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental DisordersCellular transport and secretion