The Proteomic Landscape of Centromeric Chromatin Reveals an Essential Role for the Ctf19CCAN Complex in Meiotic Kinetochore Assembly
Weronika E. Borek, Nadine Vincenten, Eris Duro, Vasso Makrantoni, Christos Spanos, Krishna K. Sarangapani, Flávia de Lima Alves, David A. Kelly, Charles L. Asbury, Juri Rappsilber, Adèle L. Marston
Abstract
-dependent kinetochore assembly pathway that is dispensable for mitotic growth but becomes critical upon meiotic entry. Therefore, changes in kinetochore composition and a distinct assembly pathway specialize meiotic kinetochores for successful gametogenesis.
Topics & Concepts
KinetochoreBiologyMeiosisCentromereCell biologyChromosome segregationCohesinGeneticsMeiosis IIChromatinChromosomeGeneMicrotubule and mitosis dynamicsDNA Repair MechanismsGenomics and Chromatin Dynamics