Simultaneous enhancement of T<sub>1</sub> and T<sub>2</sub> magnetic resonance imaging of liver tumor at respective low and high magnetic fields
Huan Li, Zijuan Hai, Liwei Zou, Lele Zhang, Lulu Wang, Longsheng Wang, Gaolin Liang
Abstract
Background: Nowadays, magnetic resonance imaging (MRI) is routinely applied in clinical diagnosis. However, using one contrast agent (CA) to simultaneously enhance the T 1 and T 2 MR contrast at low and high magnetic fields respectively has not been reported. Methods: Herein, we investigated the MR property of a -glutamyl transpeptidase (GGT)-instructed, intracellular formed gadolinium nanoparticle (DOTA-Gd-CBT-NP) at low and high magnetic fields. Results: Experimental results showed that DOTA-Gd-CBT-NP possesses a low r 2 /r 1 ratio 0.91 which enables it to enhance T 1 MR imaging of liver tumor at 1.0 T, and a high r 2 /r 1 ratio 11.8 which renders the nanoparticle to largely enhance T 2 MR imaging of liver tumor at 9.4 T.