Naturally occurring hotspot cancer mutations in Gα13 promote oncogenic signaling
Marcin Maziarz, Anthony Federico, Jingyi Zhao, Lorena Dujmusic, Zhiming Zhao, Stefano Monti, Xaralabos Varelas, Mikel Garcia‐Marcos
Abstract
mutants establish that naturally occurring hotspot mutations in Gα subunits of any of the four families of heterotrimeric G-proteins are putative cancer drivers.
Topics & Concepts
Heterotrimeric G proteinBiologyHippo signaling pathwaySignal transductionMutantGeneticsCancer researchTranscription factorCell biologyG proteinGeneHippo pathway signaling and YAP/TAZPI3K/AKT/mTOR signaling in cancerProtein Kinase Regulation and GTPase Signaling