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Proton versus photon radiotherapy for patients with oropharyngeal cancer in the USA: a multicentre, randomised, open-label, non-inferiority phase 3 trial

Steven J. Frank, Paul M. Busse, J Jack Lee, David I. Rosenthal, Mike Hernández, David Swanson, Adam S. Garden, G. Brandon Gunn, Samir H. Patel, J.W. Snider, Jeannie Daniel, Jason K. Molitoris, Nancy Y. Lee, Upendra Parvathaneni, Mark W. McDonald, Noah S. Kalman, Alexander Lin, Nasiruddin Mohammed, Christina Henson, Christian Hyde, Gopal Bajaj, Sanford Katz, Roi Dagan, William H. Morrison, Jay P. Reddy, Clifton D. Fuller, Shalin Shah, Jack Phan, Gregory M. Chronowski, Lauren L. Mayo, Erich M. Sturgis, Renata Ferrarotto, Xiaorong R Zhu, Xiaodong Zhang, Li Wang, Katherine A. Hutcheson, Adel K. El‐Naggar, Amy C. Moreno, Anna Lee, Michael T. Spiotto, Neil D. Gross, Stephen Y. Lai, Jay J. Liao, Jonathan J. Paly, Zhongxing Liao, Robert L. Foote, James E. Bates, Mark S. Chambers, Stephen G. Chun, Adeel Kaiser, Scott C. Lester, John N. Lukens, L.A. McGee, M.A. Neben-Wittich, Quynh-Nhu Nguyen, David M. Routman, Pamela J. Schlembach, Heath D. Skinner, M. Soike, Jean‐Claude M. Rwigema, Lee Wiederhold, Pierre Blanchard, I.J. Choi, Albert C. Koong, Hans Langendijk, Radhe Mohan, Barbara J Carlson, Aileen Mapps, Jeffery G Sarmiento, Menna Y. Teferra, Walter Bosch, D Followill, Paige A. Taylor, Sasha Y Fuentes, Matthew S. Ning, Iakovos Toumazis, Christine F. Wogan, Beth De Gracia, K. Fink, Adam Grippin, Jingfei Ma, Elizabeth A. Pettersen, Rasha M. Sareyeldin, Catherine Cronin, Stacey Muise, Mary L. Johnson, Kevin Pyfferoen, Briana Tranby, June Leonard, Shelby Watkin, C. Eggleston, Briana Barrow, Janette Wolcott, J. Antonio, J. J. G. van den Brand, Amy Cleverdon, Melissa Drake, Erica J. Peters, Christopher Small, Kelly Clark

2025The Lancet29 citationsDOIOpen Access PDF

Topics & Concepts

CancerMedicineNuclear medicineRadiation therapyProtonPhase (matter)Proton therapyRadiologyPhotonPhases of clinical researchHead and Neck Cancer StudiesRadiation Therapy and DosimetryAdvanced Radiotherapy Techniques
Proton versus photon radiotherapy for patients with oropharyngeal cancer in the USA: a multicentre, randomised, open-label, non-inferiority phase 3 trial | Litcius