Catalytic Transformations of 2-Pyridones by Rhodium-Mediated Carbene Transfer
Jiahui Su, Qiongya Li, Ying Shao, Jiangtao Sun
Abstract
-substituted 2-pyridones with diazo compounds has been realized by using a chiral rhodium complex as the catalyst, and the corresponding chiral cyclopropanes could be formed in good yields with high enantioselectivities. Moreover, using acceptor-acceptor dimethyl 2-diazomalonate as the carbene precursor, a novel 1,4-rearrangement of a Boc group from N to C has also been discovered under rhodium catalysis.
Topics & Concepts
CyclopropanationRhodiumCarbeneChemistryDiazoEnantioselective synthesisCatalysisAcceptorMedicinal chemistryOrganic chemistryCombinatorial chemistryPhysicsCondensed matter physicsCyclopropane Reaction MechanismsCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling Reactions