Synthesis of Aryl Sulfides by Metal‐Free Arylation of Thiols with Diaryliodonium Salts under Basic Conditions**
Sudeep Sarkar, Natalia Wojciechowska, Adam A. Rajkiewicz, Marcin Kałek
Abstract
Abstract Metal‐free arylation of thiols with diaryliodonium salts has been developed. The application of a strong organic base enables the C−S bond formation under mild and experimentally simple conditions. The method allows for the synthesis of aryl sulfides containing a broad range of aryl groups from an array of thiols, including aryl, heteroaryl, and alkyl ones. The mechanism of the reaction was studied by DFT calculations, demonstrating that it proceeds via the inner sphere pathway involving formation of an Ar 2 I(SR) intermediate, followed by reductive elimination.
Topics & Concepts
ChemistryArylAlkylReductive eliminationMetalBase (topology)Combinatorial chemistryOrganic chemistryCatalysisMathematical analysisMathematicsSulfur-Based Synthesis TechniquesSynthesis and Catalytic ReactionsChemical Synthesis and Reactions