Role of Axl in target organ inflammation and damage due to hypertensive aortic remodeling
Wei Chen, Justin P. Van Beusecum, Liang Xiao, David M. Patrick, Mingfang Ao, Shilin Zhao, Marcos G. Lopez, Frederic T. Billings, Cristina Cavinato, Alexander W. Caulk, Jay D. Humphrey, David G. Harrison
Abstract
In this study, a brief, 2-wk period of hypertension in mice led to progressive aortic remodeling, an increase in pulse wave velocity, and evidence of renal injury, dysfunction, and albuminuria. This end-organ damage was associated with persistent renal and aortic infiltration of CD8 + and γ/δ T cells. We show that this inflammatory response is likely due to GAS6/Axl signaling and can be ameliorated by blocking this pathway. We propose that the altered microvascular mechanical forces caused by increased pulse wave velocity enhance GAS6 release from the endothelium, which in turn activates Axl on myeloid cells, promoting the end-organ damage associated with aortic stiffening.