All-in-one mitochondria-targeted NIR-II fluorophores for cancer therapy and imaging
Yujia Zheng, Qianqian Li, Jing Wu, Ziyi Luo, Wenyi Zhou, Anguo Li, Yanling Chen, Tuerxunayi Rouzi, Tian Tian, Hui Zhou, Xiaodong Zeng, Yang Li, Xiaoding Cheng, Yongchang Wei, Zixin Deng, Fuling Zhou, Xuechuan Hong
Abstract
, as well as specific NIR-II tumor imaging in AML patient derived PDX mouse models for the first time. Our work lays down a solid foundation for designing small-molecule NIR-II mitochondria-selective theranostic probes.
Topics & Concepts
Photothermal therapyMitochondrionMyeloid leukemiaIn vivoCancer cellApoptosisBiophysicsChemistryOrganelleSmall moleculePEG ratioPhotodynamic therapyCancer researchCancerBiochemistryMaterials scienceNanotechnologyBiologyOrganic chemistryGeneticsEconomicsFinanceBiotechnologyNanoplatforms for cancer theranosticsAdvanced Nanomaterials in CatalysisAdvanced biosensing and bioanalysis techniques