High-Contrast Detection of Somatostatin Receptor Subtype-2 for Fluorescence-Guided Surgery
Servando Hernandez Vargas, Solmaz AghaAmiri, Sukhen C. Ghosh, Michael Luciano, Luis C. Borbon, Po Hien Ear, James R. Howe, Jennifer M. Bailey, Gregory D Simonek, Daniel M. Halperin, Hop S. Tran Cao, Naruhiko Ikoma, Martin J. Schnermann, Ali Azhdarinia
Abstract
staining of surgical biospecimens from primary and metastatic tumors, as well as involved lymph nodes, demonstrated binding to human tumors. Finally, in an orthotopic tumor model, a simulated clinical workflow highlighted our unique ability to use standard preoperative nuclear imaging for selecting patients likely to benefit from SSTR2-targeted FGS. Our findings demonstrate the translational potential of MMC(FNIR-Tag)-TOC for intraoperative imaging and suggest broad utility for using FNIR-Tag in fluorescent probe development.