The lysophosphatidic acid-regulated signal transduction network in ovarian cancer cells and its role in actomyosin dynamics, cell migration and entosis
Kaire Ojasalu, Sonja Lieber, Anna M. Sokòl, Andrea Nist, Thorsten Stiewe, Imke Bullwinkel, Florian Finkernagel, Silke Reinartz, Sabine Müller‐Brüsselbach, Robert Grosse, Johannes Graumann, Rolf Müller
Abstract
We have identified a comprehensive LPA-induced signal transduction network controlling LPA-triggered cytoskeletal changes, cell migration and entosis in HGSC cells. Due to its pivotal role in this network, MYPT1 may represent a promising target for interfering with specific functions of PP1 essential for HGSC progression.
Topics & Concepts
Lysophosphatidic acidPhosphoproteomicsCell biologySignal transductionBiologyMAPK/ERK pathwayCell migrationG protein-coupled receptorPhosphorylationProtein kinase ACellReceptorProtein phosphorylationBiochemistryErythrocyte Function and PathophysiologyPhagocytosis and Immune RegulationEndoplasmic Reticulum Stress and Disease