A Versatile Pd-Catalyzed Alkyne Annulation Process for Benzo[<i>a</i>]carbazoles and their Anticancer Analogues
Manashi Sarmah, Deep Jyoti Das, Dhiraj Dutta, Rinku Baishya, Pranjal Gogoi
Abstract
anticancer activity against human lung cancer A549 cells and human breast cancer MDA-MB-231 cells. Notably, two of the representative analogues displayed potent anticancer activity against both cancer cell lines.
Topics & Concepts
AnnulationChemistryIn vitroCombinatorial chemistryCatalysisStereochemistryAlkyneCell cultureA549 cellOrganic chemistryBiochemistryBiologyGeneticsCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsCyclopropane Reaction Mechanisms