Quantifying the transmission advantage associated with N501Y substitution of SARS-CoV-2 in the UK: an early data-driven analysis
Shi Zhao, Jingzhi Lou, Lirong Cao, Hong Zheng, Ka Chun Chong, Zigui Chen, Renee W. Y. Chan, Benny Zee, Paul K.S. Chan, Maggie Haitian Wang
Abstract
The emerging N501Y mutation in severe acute respiratory syndrome coronavirus 2, which becomes prevalent in the UK rapidly, is one of the major challenges of COVID-19 control. To explore the transmission advantage, we estimate that the N501Y substitution increases the infectivity by 52% (95% confidence interval: 46, 58) in terms of the reproduction number.
Topics & Concepts
MedicineSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Transmission (telecommunications)Coronavirus disease 2019 (COVID-19)Infectivity2019-20 coronavirus outbreakConfidence intervalBetacoronavirusSubstitution (logic)CoronavirusVirologyInternal medicineVirusDiseaseComputer scienceInfectious disease (medical specialty)OutbreakEngineeringProgramming languageElectrical engineeringSARS-CoV-2 and COVID-19 ResearchCOVID-19 epidemiological studiesCOVID-19 Clinical Research Studies