Cholesterol-lowering activity of protocatechuic acid is mediated by increasing the excretion of bile acids and modulating gut microbiota and producing short-chain fatty acids
Yimin Zhao, Zouyan He, Wangjun Hao, Hanyue Zhu, Jianhui Liu, Ka Ying, Wen‐Sen He, Zhen‐Yu Chen
Abstract
The present study aimed to investigate the effects of protocatechuic acid (PCA) on plasma lipid profiles and associated mechanisms with a focus on reshaping gut microbiota.
Topics & Concepts
CholesterolGut floraExcretionBile acidFecesCholesterol 7 alpha-hydroxylaseProtocatechuic acidShort-chain fatty acidBiologyBiochemistryInternal medicineBacteroidetesChemistryFood scienceEndocrinologyMicrobiology16S ribosomal RNAFermentationMedicineButyrateGeneAntioxidantGut microbiota and healthDiet and metabolism studiesDrug Transport and Resistance Mechanisms