Nano-infrared analysis of amyloid β<sub>1–42</sub> fibrils formed in the presence of lipids with unsaturated fatty acids
Kiryl Zhaliazka, Dmitry Kurouski
Abstract
fibrils formed in the presence of such lipids exerted significantly lower cell toxicity compared to the protein aggregates formed in the lipid-free environment. These findings suggest that dietary changes linked to the increased consumption of unsaturated phospholipids could be considered as a potential therapeutic approach that can decelerate the progression of AD. These results also suggest that large unilamellar vesicles with unsaturated lipids can be used as potential therapeutics to delay the onset and decelerate the progression of AD.
Topics & Concepts
Nano-Amyloid (mycology)FibrilChemistryInfrared spectroscopyAmyloid fibrilInfraredProtein aggregationBiophysicsAmyloid βOrganic chemistryChemical engineeringBiochemistryBiologyMedicineOpticsPhysicsPathologyDiseaseEngineeringInorganic chemistryAlzheimer's disease research and treatmentsSupramolecular Self-Assembly in MaterialsLipid Membrane Structure and Behavior