Nidogen-1 expression is associated with overall survival and temozolomide sensitivity in low-grade glioma patients
Baiwei Zhang, Cheng Xu, Junfeng Liu, Jinsheng Yang, Qinglei Gao, Fei Ye
Abstract
T cells, macrophages, neutrophils, and dendritic cells. Kaplan-Meier survival curve analysis showed that low-grade gliomas patients with high NID1 expression were associated with shorter overall survival. However, NID1 expression was not associated with overall survival in glioblastoma multiforme patients. These findings demonstrate that NID1 expression in glioma tissues is associated with overall survival of low-grade glioma patients and temozolomide sensitivity. NID1 is thus a potential prognostic biomarker and therapeutic target in low-grade glioma patients.
Topics & Concepts
TemozolomideGliomaSensitivity (control systems)OncologyMedicineInternal medicineGlioblastomaCancer researchEngineeringElectronic engineeringGlioma Diagnosis and TreatmentBrain Metastases and TreatmentMicroRNA in disease regulation