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Structure-based discovery of potent and selective small-molecule inhibitors targeting signal transducer and activator of transcription 3 (STAT3)

Qiuyao Huang, Yan Zhong, Bingbing Li, Shumin Ouyang, Linhong Deng, Jianshan Mo, Shuo Shi, Nan Lv, Ruibo Wu, Peiqing Liu, Wenhao Hu, Xiaolei Zhang, Yuanxiang Wang

2021European Journal of Medicinal Chemistry13 citationsDOIOpen Access PDF

Topics & Concepts

STAT3Drug discoveryChemistrySmall moleculeSTAT proteinActivator (genetics)Cell cultureCancer researchStructure–activity relationshipSignal transductionPhosphorylationIn vitroBiochemistryReceptorBiologyGeneticsCytokine Signaling Pathways and InteractionsSynthesis and biological activityCancer Mechanisms and Therapy
Structure-based discovery of potent and selective small-molecule inhibitors targeting signal transducer and activator of transcription 3 (STAT3) | Litcius