Cyclometalated iridium(<scp>iii</scp>) complex nanoparticles for mitochondria-targeted photodynamic therapy
Huan Lü, Xinpeng Jiang, Yanyan Chen, Ke Peng, Yiming Huang, Hao Zhao, Qi Chen, Fengting Lv, Libing Liu, Shu Wang, Yuguo Ma
Abstract
ppy NPs, thus the distribution of the therapeutic agents in mitochondria can be tracked by confocal laser scanning microscopy (CLSM). The mechanism of killing cancer cells under irradiation is investigated, and the results indicate that cell death is caused by mitochondria-mediated apoptosis, which is induced by the ROS generated under light irradiation.
Topics & Concepts
IridiumNanoparticlePhotodynamic therapyMitochondrionIrradiationSolubilityWhite lightChemistryMaterials scienceBiophysicsPhotochemistryCombinatorial chemistryNanotechnologyBiochemistryCatalysisBiologyOrganic chemistryOptoelectronicsPhysicsNuclear physicsNanoplatforms for cancer theranosticsLuminescence and Fluorescent MaterialsAdvanced biosensing and bioanalysis techniques