Cytotoxic Ag(I) and Au(I) NHC-carbenes bind DNA and show TrxR inhibition
Federica Guarra, Natalia Busto, Annalisa Guerri, Lorella Marchetti, Tiziano Marzo, Begoña Garcı́a, Tarita Biver, Chiara Gabbiani
Topics & Concepts
ChemistryThioredoxin reductaseCarbeneCytotoxicityDNALigand (biochemistry)CisplatinStereochemistryFluorescenceEnzymeBiochemistryCombinatorial chemistryIn vitroThioredoxinReceptorQuantum mechanicsSurgeryMedicineChemotherapyPhysicsCatalysisN-Heterocyclic Carbenes in Organic and Inorganic ChemistryFerrocene Chemistry and ApplicationsSynthesis and Biological Evaluation