Neurotrophic Factors Protect the Intestinal Barrier from Rotavirus Insult in Mice
Marie Hagbom, Felipe Meira de‐Faria, Martin E. Winberg, Sonja Westerberg, Johan Nordgren, Sumit Sharma, Åsa V. Keita, Vesa Loitto, Karl‐Eric Magnusson, Lennart Svensson
Abstract
Human and mouse studies have shown that rotavirus infection is associated with low inflammation and unaffected intestinal barrier at the time of diarrhea, properties different from most bacterial and inflammatory diseases of the gut. We showed by in vitro , ex vivo , and in vivo experiments that neurotrophic factors and 5-HT have barrier protective properties during rotavirus insult. These observations advance our understanding of how the gut barrier is protected against rotavirus and suggest that rotavirus affects the gut barrier differently from bacteria. This is the first report to show that neurotrophic factors contribute to maintain the gut epithelial barrier during viral insult.