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A PKA inhibitor motif within SMOOTHENED controls Hedgehog signal transduction

John T. Happ, Corvin D. Arveseth, Jessica Bruystens, Daniela Bertinetti, Isaac Nelson, Cristina Olivieri, Jingyi Zhang, Danielle Hedeen, Ju‐Fen Zhu, Jacob L. Capener, Jan W. Bröckel, Lily Vu, Charles C. King, Víctor L. Ruiz‐Pérez, Xuecai Ge, Gianluigi Veglia, Friedrich W. Herberg, Susan S. Taylor, Benjamin R. Myers

2022Nature Structural & Molecular Biology65 citationsDOIOpen Access PDF

Topics & Concepts

SmoothenedHedgehogCell biologySignal transductionG protein-coupled receptorBiologyHedgehog signaling pathwayWnt signaling pathwayProtein kinase APhosphorylationPatchedKinaseChemistryBiochemistryHedgehog Signaling Pathway StudiesChromatin Remodeling and CancerEpigenetics and DNA Methylation
A PKA inhibitor motif within SMOOTHENED controls Hedgehog signal transduction | Litcius