Cross-talk between CD38 and TTP Is Essential for Resolution of Inflammation during Microbial Sepsis
Yeonsoo Joe, Yingqing Chen, Jeongmin Park, Hyo Jeong Kim, So‐Young Rah, Jinhyun Ryu, Gyeong Jae Cho, Hye‐Seon Choi, Stefan W. Ryter, Jeong Woo Park, Uh‐Hyun Kim, Hun‐Taeg Chung
Abstract
levels, suppresses the acute inflammatory response and decreases Rheb expression, inhibits mTORC1, and induces autophagolysosomes for bacterial clearance. TTP may represent a mechanistic target of anti-inflammatory agents, such as carbon monoxide. TTP mediates crosstalk between acute inflammation and autophagic clearance of bacteria from damaged tissue in the resolution of inflammation during sepsis.
Topics & Concepts
InflammationNAD+ kinaseCD38ChemistryCell biologyBiologyImmunologyBiochemistryEnzymeStem cellCD34Calcium signaling and nucleotide metabolismAutophagy in Disease and TherapyErythrocyte Function and Pathophysiology